- What is generic Levitra?
- Mechanism of action
- How long does generic Levitra effects last?
- How long does it take for generic Levitra to work?
- How long does Levitra stay in your system?
- What are the side effects of Levitra?
- Drug Interactions
- Is generic Levitra safe?
- Generic Levitra analogs:
Basic Drug Info
Manufacturer: Sunrise Remedies, Dadha Pharma
Active Substance: Vardenafil citrate
Drug Form: Film-coated tablets
Available Doses: 10mg, 20 mg
What is generic Levitra?
Generic Levitra contains vardenafil, which belongs to the family of drugs called phosphodiesterase type 5 inhibitors. These drugs are used in the treatment of compromised erectile function in adult males, or ED (erectile dysfunction) – a disease that results in difficulties in achieving or maintain an erection. It was introduced with the aim of representing a faster and more powerful alternative to Viagra, but, in reality, has been shown to have very similar characteristics. The only advantage is that it has a slightly higher absorption than Viagra, when taken with a meal.
At least one in ten men sometimes have difficulty getting or maintaining an erection. The causes can be physical or psychological, or most often a mixture of both. Whatever the cause, due to a change in the muscles and blood vessels, there is not enough blood left in the penis to make it rigid and rigid.
Generic Levitra will only act in case of sexual stimulation. It reduces the action of a chemical in the body that stops the erection. Generic Levitra allows an erection of sufficient duration for a satisfactory sexual intercourse.
Mechanism of action
In the case of sexual stimulation, the body responds by producing a substance, the cyclic guanosine monophosphate (cGMP) which, by promoting blood supply to the penis, causes an erection. The greater the concentration of this substance, the greater the extent and duration of the erection. However, the body also naturally produces another substance, phosphodiesterase 5 (PDE5) which dissolves cyclic guanosine monophosphate. Consequently, if high levels of phosphodiesterase 5 are present in the body, the levels of cyclic guanine monophosphate are reduced and, even in the case of sexual stimulation, an erection is not achieved, is negligible or not very lasting.
Starting from the principle that generic Levitra is not an aphrodisiac, as it does not increase sexual desire, vardenafil mechanism is limited to increase the blood flow in the penis, favoring the achievement of an erection, making it more vigorous and lasting. But it must be borne in mind that it is always necessary for this to be initially facilitated by appropriate stimuli to obtain the organ’s swelling, in order to achieve satisfactory results in terms of efficiency and tolerability, since without sexual stimulation the drug does not work.
How long does generic Levitra effects last?
The effects of Levitra last during 4 to 6 hours. The half-life of the drug largely depends on objective differences that are present in every individual taking the drug. In patients with compromised kidney or liver function, vardenafil takes longer to get metabolized, and therefore stays in the body for a longer period of time, up to 6 hours. In certain cases it is advisable to consider taking smaller doses of vardenafil for that matter.
How long does it take for generic Levitra to work?
Once the PDE5 enzyme has been inactivated, calcium levels within the cells in the smooth muscle of the penis increase considerably. This relaxes the muscle and allows the blood to flow better. And with better blood flow, user can have a better erection. However all the drug only works in presence of sexual stimulation. That is, without an external stimulus, erection will not take place, which also rules out the possibility of developing spontaneous erections.
Generic Levitra is taken 25 minutes before planned sexual activity, which is much sooner than the recommended onset time allowance for most of other drugs in its class.
The average dose is 10 mg taken on demand, which is in case sexual intimacy is planned, approximately 25 to 60 minutes before sexual activity. Depending on the efficacy and tolerance, the dose may be stepped up to 20 mg or decreased to 5 mg. Generic Levitra 20 mg is the maximal dose with established safety. It is recommended to use the drug at most once a day. Generic Levitra can be taken with or without food. The delay in action may be delayed if taken during a high-fat meal.
How long does Levitra stay in your system?
The body will be ready for a new erection during the period of 6 hours; with the right stimulation a good erection can also occur. However we are not talking about an erection that lasts several hours. You will experience a normal orgasm and erection, the only difference is that a new erection can be achieved more quickly than usual, as the body continues to be under the effect of the drug.
What are the side effects of Levitra?
As mentioned above, generic Levitra were not designed for the treatment of erectile dysfunction, but as vasodilators. Thanks to this property, some of them are approved for use in some forms of pulmonary hypertension and in the prevention of high altitude pulmonary edema.
The undesirable effects of generic Levitra are: dyspepsia, nausea, vomiting, headache (including migraine), flushing, dizziness, myalgia, low back pain, visual disturbances (reported non-arteritic anterior ischemic optic neuropathy) – stop taking in case of sudden sight difficulty), nasal congestion. Less common red and painful eyes, palpitations, hypotension, hypertension, epistaxis. Rarely reported syncope, hypersensitivity reactions (including skin rash, facial edema, Stevens-Johnson syndrome) and priapism. Severe cardiovascular events (including arrhythmias, unstable angina and myocardial infarction) and retinal vascular occlusion have also been reported.
The following conditions represent relative (ie less stringent) contraindications to the use of generic Levitra:
- ischemic heart disease (although some studies have shown that Viagra & co do not lead to an increased risk of heart attack or re-infarction);
- taking other vasodilator drugs (such as α-lithics);
- severe liver disease;
- severe renal failure;
- retinitis pigmentosa and some other eye diseases.
Generic Levitra is contraindicated in patients taking nitrates, in patients in whom vasodilation and sexual activity are not recommended or in patients with previous non-arteritic anterior ischemic optic neuropathy. For lack of information, manufacturers advise against these drugs in case of hypotension (systolic blood pressure less than 90 mmHg), recent stroke, unstable angina and myocardial infarction.
Generic Levitra should be used with caution in case of cardiovascular diseases, obstruction of the left ventricular outflow tract, anatomical deformation of the penis (eg angulation, cavernous fibrosis, Peyronie’s disease) and in subjects with predisposition to priapism (eg in sickle-cell anemia, multiple myeloma or leukemia).
Phosphodiesterase-5 inhibitors are absolutely contraindicated in the case of simultaneous intake of nitroderivative drugs (such as trinitrine or sodium nitroprusside), since the synergistic effect of vascular dilation can cause significant and potentially very serious pressure drops. The same goes for anti-fungal drug, HIV/AIDS drugs and other inhibitors of PDE5.
Is generic Levitra safe?
Is there a risk of some side effects in taking generic drugs? No, but one should pay attention to the purchase of pills online: often products that come from other countries are sold on the web, where there are not the same controls in the composition. The risk in this case is to take pills with various excipients and to have unplanned or unforeseeable side effects.
Phosphodiesterase-5 inhibitors are substantially safe drugs. The most frequently reported side effects are headache and skin redness, both due to the dilation effect of blood vessels. So these are annoying but mild reactions and, in any case, tend to regress over time, once you get used to the drug. Other rarer side effects are mild intestinal disorders, nasal congestion, visual changes, dermatitis, back pain and muscle pain.
Generic Levitra analogs:
- Vitria – Dadha Pharma
- Zhewitra – Parex Pharmaceuticals
- Snovitra – Sunrise Remedies
- Viprofil – VIPRO Lifescience
- Filitra – Dadha Pharma