Nolvadex

What is Nolvadex?

Nolvadex is a selective anti-oestrogenic drug used in the treatment of breast cancer and has recently been re-evaluated for the short-term treatment of anovulatory female infertility.

What is Nolvadex used for?

Estrogens are a naturally occurring substance in the body known as “sex hormones”. Nolvadex works by blocking the effects of estrogen on your body. Nolvadex is indicated:

  • in the treatment of breast cancer;
  • in men in the prevention and treatment of breast augmentation (gynecomastia) and breast pain (mastalgia) caused by medicines called antiandrogens and used in the treatment of prostate cancer (prostate cancer), a gland that produces in humans the seminal fluid.

Talk to your doctor if you do not feel better or if you feel worse.

What does Nolvadex do?

Tamoxifen is administered after surgical treatment in pre and post-menopausal patients to reduce the risk of relapse. Tamoxifen is usually administered after the conclusion of chemotherapy. Tamoxifen is often administered before surgery to reduce the size of the tumor so that excision can be limited to the nodule rather than extended to the whole breast (mastectomy).

Tamoxifen is sometimes used to keep the disease under control, often for long periods of time, and also to reduce the size of a tumor that has recurred after treatment or that cannot be removed because it is too large at the time of the first diagnosis.

How to take Nolvadex?

Nolvadex is administered in the correct dose to patients for daily intake, with the regular doses ranging between tamoxifen 20 mg and 40mg daily. One tablet of Nolvadex contains 10mg or 20mg of the active substance. The dose is appointed by the supervising healthcare practitioner. The required dose can be split between two intakes or taken as a single dose. Dose adjustment is not required in the geriartrics.

Tamoxifen is given by mouth. The dose is preferably taken at the same time. Since tamoxifen can cause nausea and leave a metallic taste in the mouth, some patients prefer to take it when during meals.

Nolvadex or Clomid – what to choose?

Both Nolvadex and Clomid are a serum to use in eg PCT. Some people react a little differently to them. Nolvadex is considered to be a little more effective and give lesser side effects in general.

In men, Clomid can be used both as an antiestrogen, and a gonadotropic stimulant (which stimulates the glands). Male steroid users find it helpful to prevent gynecomastia when using steroids. It also helps to restore your own testosterone production to the normal, after completed steroid cycle, Clomid acts directly on the pituitary gland that is stimulated to increase the production of gonadotropic hormones. No adverse effects have been observed in those who have used this drug. It can be quite effective, but not more effective than HCG or Novaldex in this area. The most common dose during short courses is 50 mg per day.

Nolvadex or Arimidex?

The two medications, Nolvadex and Arimidex, are applied with the same purpose of anti-estrogen agents. The mechanism of action is different for Nolvadex and Arimidex, while their medicational purposes are the same. Arimidex lowers the estrogen levels in the body, while Nolvadex blocks certain receptors (does not lower estrogen).

In bodybuilding, Nolvadex usually gives less side effects, but it is individual. However, in some cases it is better to use Arimidex during the course to avoid the gynecomastia phenomenon and restrict Nolvadex use for PCT.

In addition, it is good to continue with the Arimidex about 3 weeks after the end of the course (after starting with Clomid) as it also increases the body’s own testosterone production. Along with virtually zero aromatization it contribues to complete recovery.

Nolvadex and Proviron

In comparison to Nolvadex, Proviron is reported to have fewer and milder side effects. Nolva or Proviron counteract both estrogen conversion in different ways.

Proviron is a low androgenic steroid that promotes lean muscle mass gains and protects against gynecomastia taken in the doses between 50mg and 100mg. Proviron is usually taken as a part of PCT in subjetcs with poor response to Nolvadex in order to increase testosterone production and augment sex drive. However, Nolvadex is generally considered to be better than Proviron against water retention.

Nolvadex and PCT

Both Nolvadex and Clomid are a serum to use in eg PCT. Different people react a little differently to them. Nolvadex is considered to be a little more effective and give fewer side effects in general.

Nolvadex is an effective antiestrogen, not a steroid. It is used against estrogen dependent tumors, e.g. breast cancer. Steroid users take Nolvadex to prevent the effects of estrogen in the body. This estrogen is usually a result of aromatizing steroids. Nolvadex can help prevent edema, gynecomastia and female fat distribution, all of which can occur when a man has a high estrogen level. These effects can also occur at too low androgen levels, as estrogen becomes the dominant hormone. This can happen when the endogenous androgens are suppressed as a result of prolonged use of exogenous steroids.

Nolvadex works by binding to receptors in the target estrogen region, e.g. in the breasts, so that it competes with the estrogen. This drug is not toxic, and some side effects have not been observed in athletes who used it as an antiestrogen. This is the most popular antiestrogen among steroid users. Although it does not appear to be 100% effective in everyone, it seems to have a certain effect for most people. In some bodybuilders it seems so good that they can take medicines like Anadrol right before a competition, as long as they combine these with Nolvadex.

Tamoxifen side effects

Long-term therapy, necessary for the treatment of breast cancer, exposes the patient to numerous side effects linked to the use of tamoxifen.

More precisely, hot flashes, vaginal blood loss, skin rash, dermatitis, hydro-saline retention, dizziness, visual disturbances, lower limb cramps, volumetric increase in ovarian cysts, hepatic steatosis and liver failure are the most frequently observed adverse reactions in progress of therapy with Nolvadex.

However, those that are of most concern, assuming particular importance from the clinical point of view, are linked to the greater incidence of developing embolic thrombus events and malignant pathologies concentrated mainly in the uterine and endometrial area.

Precautions

Nolvadex should be administered with caution in patients with a decrease in the number of blood cells (leukopenia) and with a decrease in the number of platelets (thrombocytopenia). Therefore, regular blood tests should be performed. Tamoxifen can cause cataracts, so eye checks must be performed.

As Nolvadex can cause alterations – even serious – of the uterus, regular gynecological checks should be performed.

Contraindications

The use of Nolvadex is contraindicated in the following cases:

  • Known hypersensitivity to tamoxifen;
  • As a preventive therapy in patients at high risk of developing breast cancer;
  • In patients with ductal carcinoma in situ (an initial form of breast cancer, also called precancerous);
  • In patients who require concurrent anticoagulant therapy;
  • In patients with a history of deep vein thrombosis;
  • In patients with a history of pulmonary embolism;
  • In children and adolescents;
  • Pregnancy;
  • During breastfeeding.

Where to buy Nolvadex

Nolvadex can be ordered online, which is a better way to save money on pharmacy shopping, and a more hassle-free routine as compared to getting the medication at an actual pharmacy store. A healthcare specialist can consult you as for the right use of the medication if you choose an e-drugstore with an in-house practitioner, and your Nolvadex pills will be delivered to you in average within 10 work days, anonymously and safely.

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