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Sildenafil Citrate


Orde- Nizagara-100 mgNizagara (Sildenafil Citrate) it an effective vasodilating medicine used for managing erectile dysfunction (ED), which is a common condition in men of different ages. The active ingredient of the medicine is sildenafil citrate (sil-DEN-a-fil). It is sold in tablets containing 100mg of the main component. Other medications that have the same active ingredient are Revatio and Viagra.

The medication can be also prescribed for people with pulmonary hypertension.

Mechanism of Action

Erection occurs as a result of a complex chain of chemical reactions in the body. Sexual stimulation initiates release of nitric oxide in the cavernous body of the penis, which results in activation of the enzyme guanylate cyclase, leading to increasing cGMP. As a result, the smooth muscles of the blood vessels relax and dilate, allowing blood to flow easily.

Sildenafil works by enhancing the effect of nitric oxide thanks to the ability to inhibit PDE5. It is important to note that the drug does not have a direct relaxant effect on corpus cavernosum, but it activates the necessary processes in the body. The medicine does not work without sexual stimulation, which is responsible for the initial release of nitric oxide.

Dosages and Administration

Take Nizagara tablets with a full glass of water. It is not recommended to have a high-fat meal with it because this may delay the onset of action. For the best effect, the drug should be taken on an empty stomach. Use the medication at least 30 min. before having sexual intercourse.

The recommended dosage is 100mg for the adult man; however, it may be adjusted a healthcare provider based upon many factors, such as age, health condition, other medications taken, tolerability, effectiveness, and others.

The maximum daily dosage is 100mg. At least 24 hours should pass before taking another dosage of the drug. You may need to decrease your dosage to 50mg if you experience a headache due to the use of the drug. Men older 60 years old are recommended to start taking the drug with 25 mg.

Sildenafil for Pulmonary Hypertension

According to the clinical studies, sildenafil is also effective in lowering the pulmonary pressure, which is the high pressure in arteries vascularized lungs. It may be caused due to the pulmonary fibrosis and various inflammatory processes. Patients with this disease suffer from the decreased ability of lungs to get oxygen, which results in a range of unpleasant symptoms, such as:

  • Shortness of breath;
  • Fatigue;
  • Dizziness;
  • Chest pain.
  • Swelling different parts of the body.


Since Nizagara tablets contain sildenafil, it can be used in treating this disorder. It acts by dilating the vessels and, thus, improving the blood circulation in the lungs.

The medicine can be used for the treatment of this health condition only if it is recommended by a healthcare provider and only in accordance with his or her recommendations. A patient may be asked a range of questions, which is necessary to ensure the safe use of the drug. For instance, your doctor will need to know the following:

  • What other diseases you may have?
  • What other medication do you take?
  • Do you have an allergy to any medicine or substance?

Side Effects


  • Headache;
  • Dizziness;
  • Muscle/back pain;
  • Insomnia;
  • Flushing;
  • Vision problems;
  • Runny/stuffy nose;
  • Indigestion.

Serious (require urgent medical help):

  • Heart attack symptoms;
  • Vision loss;
  • Painful erection;
  • An erection that lasts for more than four hours;
  • Hearing loss;
  • Arrhythmias;
  • Breathing problems;
  • Convulsions.

This medicine should not be used in men who experience serious side effects.